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FOXQ1 utilizes the KMT2A/MLL complex as a transcriptional co-activator of EMT in breast cancer
Forkhead box Q1 (FOXQ1) recruits the KMT2A/MLL histone methyltransferase to gene regulatory regions by binding to RbBP5. In this study, we uncover the protein interaction mechanism and demonstrate how this transcriptional pathway could be exploited to suppress FOXQ1-mediated EMT and metastasis.
GRAMD1C-mediated cholesterol transport regulates autophagosome biogenesis and mitochondrial bioenergetics
In their study, Ng and coworkers identified the cholesterol transport protein GRAMD1C as a negative regulator of autophagy and mitochondrial bioenergetics and explored its link to Clear Cell Renal Carcinoma (ccRCC).
Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows.
Africa and Cancer
Facilitating collaborative cancer research programs and research capacities in Africa
Garissa Cancer Center: Inaugural Oncology Facility in Northern Kenya region in 60 years
Your geographic locale, ethnicity, education, environmental injustices, and access to a health care system are your social determinants of health and health inequities~ World health organisation
Cervical Cancer: The African perspective
Sub-Saharan Africa records the highest number of cases and deaths of cervical cancer annually making cervical cancer one of the biggest threats to African women.
Black in Cancer
Strengthening networks and highlighting Black excellence in cancer research and medicine.
Cervical Cancer: The African perspective
Sub-Saharan Africa records the highest number of cases and deaths of cervical cancer annually making cervical cancer one of the biggest threats to African women.
Opportunities to join the Nature Communications editorial team
We are seeking two cancer research experts to join our cancer team; one role is for a permanent team member, the second role is for a locum - or a temporary position.
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