Nature Comms
Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Here we investigate the impact of different immune pressure on tumor clonal dynamics and immune evasion mechanism, by combining massive parallel sequencing of immune edited tumors and CRISPR library screens in syngeneic mouse tumor model and co-culture system.
Molecular and Phenotypic profiling of Colorectal Cancer patients in West Africa reveals biological insights
Very little is known about the biology of Colorectal cancer in West Africa. This study provides novel insights on the subject
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
This post details some of the motivation and concepts of our paper, and why we decided to focus on a different type of observable phenotype within CRISPR genetic screens.
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective cytotoxic activity in neuroblastoma
Our recent study revealed that the chemotherapeutic CX-5461 primarily binds and inhibits TOP2B, exhibiting selective cytotoxicity in neuroblastoma cells, which overexpress TOP2B. As such, pharmacological targeting of TOP2B raises safety concerns due to off-target drug interactions with this gene.
