Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche
Our study sought to identify key elements of the tumor microenvironment (TME) that drive distinct tumor states by defining the spatial organization of the TME. We find the proliferative neighborhood matures TREM2+ immunosuppressive myeloid cells into a self-propagating tumor-immune niche.
Antimicrobial exposure is associated with decreased survival in triple-negative breast cancer
Read the paper: https://rdcu.be/c9Nkz
Liquid biopsy profiling for the detection of therapy evasion and tumor evolution in breast cancer
In a large cohort of patients with breast cancer who received tissue and liquid biopsy-based genomic profiling, we portray the utility of liquid biopsies in better understanding the tumor evolution, monitoring progression and resistance, and identifying rare targets for treatment.
FOXQ1 utilizes the KMT2A/MLL complex as a transcriptional co-activator of EMT in breast cancer
Forkhead box Q1 (FOXQ1) recruits the KMT2A/MLL histone methyltransferase to gene regulatory regions by binding to RbBP5. In this study, we uncover the protein interaction mechanism and demonstrate how this transcriptional pathway could be exploited to suppress FOXQ1-mediated EMT and metastasis.
GRAMD1C-mediated cholesterol transport regulates autophagosome biogenesis and mitochondrial bioenergetics
In their study, Ng and coworkers identified the cholesterol transport protein GRAMD1C as a negative regulator of autophagy and mitochondrial bioenergetics and explored its link to Clear Cell Renal Carcinoma (ccRCC).
