Integrated transcriptome study of the tumor microenvironment for treatment response prediction in male predominant hypopharyngeal carcinoma
Characterization of an RNA binding protein interactome reveals a context-specific posttranscriptional landscape of MYC-amplified medulloblastoma
In a large cohort of patients with breast cancer who received tissue and liquid biopsy-based genomic profiling, we portray the utility of liquid biopsies in better understanding the tumor evolution, monitoring progression and resistance, and identifying rare targets for treatment.
Forkhead box Q1 (FOXQ1) recruits the KMT2A/MLL histone methyltransferase to gene regulatory regions by binding to RbBP5. In this study, we uncover the protein interaction mechanism and demonstrate how this transcriptional pathway could be exploited to suppress FOXQ1-mediated EMT and metastasis.
GRAMD1C-mediated cholesterol transport regulates autophagosome biogenesis and mitochondrial bioenergetics
In their study, Ng and coworkers identified the cholesterol transport protein GRAMD1C as a negative regulator of autophagy and mitochondrial bioenergetics and explored its link to Clear Cell Renal Carcinoma (ccRCC).
The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The many faces of endothelial cells in healthy and malignant breast tissue – from angiogenesis to immunoregulation and lipid processing