Melanoma loss of IFN-g signaling is a major mechanism of resistance to immune checkpoint blockers such as anti-CTLA-4 and anti-PD-1, a prominent type of immunotherapies offering unprecedented therapeutic hopes to melanoma patients. However, strategies of overcoming this resistance have been elusive.
Clinically-relevant models reveal new insights into patient heterogeneity and hormone action in estrogen receptor positive (ER+) breast cancer.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a rising incidence in the United States and globally. Effective strategies to prevent and treat PDAC are urgently needed. The majority of PDACs arise from pancreatic intraepithelial neoplasia (PanIN) pre-cancerous lesions.
Antibody-positron emission tomography (immunoPET) show the potential of temporal and controlled modulation of receptor membrane availability to enhance antibody efficacy.
Comments and future work for"PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation"
We have comments and plan work in the future for the work done by our lab for the paper "PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation" .