Nature Comms
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
This post details some of the motivation and concepts of our paper, and why we decided to focus on a different type of observable phenotype within CRISPR genetic screens.
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective cytotoxic activity in neuroblastoma
Our recent study revealed that the chemotherapeutic CX-5461 primarily binds and inhibits TOP2B, exhibiting selective cytotoxicity in neuroblastoma cells, which overexpress TOP2B. As such, pharmacological targeting of TOP2B raises safety concerns due to off-target drug interactions with this gene.
Building translational understanding of pediatric radiation-induced gliomas, an unmet need in childhood cancer
Pediatric radiation-induced gliomas (RIGs) are high-grade brain tumors caused by radiation kids received for a previous cancer. These incurable tumors have had little research attention. We conducted a study of drivers and potential treatments of RIG in the largest patient sample set ever assembled.
