The realization of direct-acting agents targeting the MYC oncogene has been a long-standing challenge in cancer therapeutics. Our recent paper describes new antisense tools with potent anti-MYC effects.
We show the importance of hypoxia in activating enzymes that control proper collagen maturation in eye melanoma. Disrupting this process with an inhibitor of the HIF-1/p300 transcription complex leads to disordered collagen structure and reduces tumor growth in the eye and liver in mice xenografts.
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