CUL4B is first identified as a mental retardation gene in our laboratory. We further confirmed that CUL4B also functions importantly in cancer. In our latest publication, we revealed CUL4B sustained the oncogenic properties in bladder cancer through regulating miR-372/373-PIK3CA/AKT axis.
Endocrine tumors frequently show PKA activation even in the absence of mutations in relevant genes. Here we used GH-secreting pituitary tumor cells to discover a novel mechanism through which hypoxia and HIF-1α activate PKA by altering the expression of the regulatory RIIB subunit.
C1orf35 is a gene first cloned and identified in our laboratory, but little is known about its function. We confirmed it a candidate oncogene in the current study, and explored how it promote tumorigenesis.
Lactate, a tumour-cell metabolite, promotes immune evasion via GPR81: A potential novel strategy to boost cancer immunotherapy?
Tumour cells generate lactate as a signaling molecule to aid in growth and metastasis. We have uncovered a novel function for this metabolite; it blunts the ability of the body’s immune system to recognize and kill tumour cells, thus making it possible for the cancer to evade immune attack.