Oncogene
This journal aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research.
Mitochondria chaperone-mediated stability of SIX1 opens a door for prostate cancer progression and castration resistance
This work shows how mitochondria chaperone GRP75 regulates the stability of SIX1, a transcription factor for embryonic development and cancer progression. Our findings provide important insights into the protein degradation mechanism as well as a novel avenue for prostate cancer therapy.
CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma
In our study in Oncogene, we demonstrate that CPSF4 acts as an oncogene in HCC through circRNA inhibition and disruption of miRNA-mediated gene silencing.
The story of walking on a resistant trail: TRAIL-resistance in GBM
Cingöz et al. Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization. Oncogene, 2021.
https://www.nature.com/articles/s41388-021-01697-6
Exosomes secreted from cancer-associated fibroblasts in malignant lymphoma
In our study in Oncogene, we demonstrate that exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter, ENT2, in malignant lymphoma.
Artificial Intelligence, Cancer, and Azithromycin
The explosion of available data and revolution in algorithms have created a moment with infinite potential.