Tarek H. Mouhieddine, MD

Ewing sarcoma is a pediatric cancer characterized by chimeric EWSR1-ETS fusion oncogenes (in 85% EWSR1-FLI1). In our recent study, we showed that EWSR1-FLI1 hijacks the developmental transcription factor SOX6, which contributes to tumor growth but also increases sensitivity toward oxidative stress.

Binod Dhakal, Anita D'Souza, Saurabh Chhabra, Parameswaran Hari, Medical College of Wisconsin Milwaukee, WI, USA

HCL is a rare disease and the therapeutic management could be a suject of discussion. We present here the different options in newly and relapsed/refractory HCL patients.