Horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein through secreted vesicles
José Manuel García-Heredia, Daniel Otero-Albiol, Marco Pérez, Elena Pérez-Castejón, Sandra Muñoz-Galván and Amancio Carnero; Instituto de Biomedicina de Sevilla (IBIS/HUVR/Universidad de Sevilla/CSIC); CIBERONC
Phosphoproteomic profiling in leukaemia illuminates treatment targets that are invisible to genomics, but how do we bring them to the clinic...
Our work published in Nature Communications describes how non canonical Wnt signalling supports melanoma stem cell properties and amoeboid invasion. We observe such tight regulation at the tumour invasive front. This set of signals supports tumour growth and metastasis.