Forkhead box Q1 (FOXQ1) recruits the KMT2A/MLL histone methyltransferase to gene regulatory regions by binding to RbBP5. In this study, we uncover the protein interaction mechanism and demonstrate how this transcriptional pathway could be exploited to suppress FOXQ1-mediated EMT and metastasis.

In their study, Ng and coworkers identified the cholesterol transport protein GRAMD1C as a negative regulator of autophagy and mitochondrial bioenergetics and explored its link to Clear Cell Renal Carcinoma (ccRCC).