Nature Cancer
APOBEC3A – a causative agent in cancer-related chromosomal instability and STING driven metastasis
Chromosomal instability (CIN) is a hallmark of cancer and has been associated with a highly metastatic phenotype in numerous cancers. We identified a novel function for APOBEC3A in the initiation of CIN featuring enhanced, STING-dependent, distant organ seeding, and metastatic growth.
Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
The story started from a simple but unanswered question: what is the cellular function of pseudouridine, the most frequent epitranscriptomic modification, in cancer?
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent anti-tumor response
The type 1 NKT cell stimulating glycolipid α-galactosylceramide (α-GalCer) was first identified by the Pharmaceutical Research Laboratory of Kirin Brewery in a screen for novel anti-tumor agents. Based on promising preclinical data it was tested as an anticancer drug in multiple clinical studies.
