Nature Cancer
This journal aims to provide a unique forum through which the cancer community will learn about the latest, most significant cancer-related advances across the life, physical, applied and social sciences.
APOBEC3A – a causative agent in cancer-related chromosomal instability and STING driven metastasis
Chromosomal instability (CIN) is a hallmark of cancer and has been associated with a highly metastatic phenotype in numerous cancers. We identified a novel function for APOBEC3A in the initiation of CIN featuring enhanced, STING-dependent, distant organ seeding, and metastatic growth.
Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
The story started from a simple but unanswered question: what is the cellular function of pseudouridine, the most frequent epitranscriptomic modification, in cancer?
