Chromosomal instability (CIN) is a hallmark of cancer and has been associated with a highly metastatic phenotype in numerous cancers. We identified a novel function for APOBEC3A in the initiation of CIN featuring enhanced, STING-dependent, distant organ seeding, and metastatic growth.
The story started from a simple but unanswered question: what is the cellular function of pseudouridine, the most frequent epitranscriptomic modification, in cancer?
The type 1 NKT cell stimulating glycolipid α-galactosylceramide (α-GalCer) was first identified by the Pharmaceutical Research Laboratory of Kirin Brewery in a screen for novel anti-tumor agents. Based on promising preclinical data it was tested as an anticancer drug in multiple clinical studies.
We and selected partners, use cookies or similar technologies as specified in the cookie policy and privacy policy.
You can consent to the use of such technologies by closing this notice.
×
Cookie Control
Customise your preferences for any tracking technology
The following allows you to customize your consent preferences for any tracking technology used
to help us achieve the features and activities described below. To learn more about how these trackers help us
and how they work, refer to the cookie policy. You may review and change your preferences at any time.
These trackers are used for activities that are strictly necessary to operate or deliver the service you requested from us and, therefore, do not require you to consent.
These trackers help us to provide a personalized user experience by improving the quality of your preference management options, and by enabling the interaction with external networks and platforms.
Nature Portfolio Cancer Community is for all those interested in cancer research, including our journal readers and authors, educators, and those working in medicine, industry and healthcare