Large population-based study identifies that tumor size and lymph node involvement are associated with risk of death in metastatic breast cancer
Towards a New Diagnostic to Identify Lung Cancer Patients Who Respond to Immunotherapy by Analyzing Blood-born microRNAs
Timothy Rajakumar, MD, PhD & Bruno Steinkraus, PhD
Transcriptome analysis reveals key information about a rare pediatric cancer and response to immune checkpoint inhibitor monotherapy
Besides eradicating tumour cells with deficiencies for homologous recombination, PARP inhibitors can induce the activation of CAFs within the TME via NF-κB/CCL5 pathway. CCL5 blockade blunts the reprogramming of CAFs conditioned by PARP inhibitors and potentiates PARP inhibitors.