Multiplex bioimaging of single-cell profiles in patient biopsies and artificial intelligence analysis of spatially distinct patient cohorts inform personalized cancer treatments.

We found that the most common polymorphism known to affect the MET gene (Asn375Ser [N375S]) increases the aggressiveness of squamous cell carcinoma of the lung, head and neck, and is unexpectedly amenable to HER2 blockers but resistant to c-Met inhibitors.

Using CRISPR based screening, we discovered that activation of the integrated stress response pathway enhances PD-L1 translation and promotes immune suppression in lung cancer.

Written by Tixier F, Hatt M, Cheze-le-Rest C, Corcos L and Visivikis D