Tarek H. Mouhieddine, MD
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Ewing sarcoma is a pediatric cancer characterized by chimeric EWSR1-ETS fusion oncogenes (in 85% EWSR1-FLI1). In our recent study, we showed that EWSR1-FLI1 hijacks the developmental transcription factor SOX6, which contributes to tumor growth but also increases sensitivity toward oxidative stress.
A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study
Binod Dhakal, Anita D'Souza, Saurabh Chhabra, Parameswaran Hari, Medical College of Wisconsin Milwaukee, WI, USA