Our work published in Nature Communications describes how non canonical Wnt signalling supports melanoma stem cell properties and amoeboid invasion. We observe such tight regulation at the tumour invasive front. This set of signals supports tumour growth and metastasis.

This blog reflects on the journey that led to the publication of our preoperative combination immunotherapy study in Nature Medicine.

What value does deciphering the whole genome hold for guiding clinical care of children with high-risk cancer? Does it provide more accurate diagnoses, more treatment options, better risk stratification? Can it be analyzed fast enough to have real-time clinical impact?