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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Ewing sarcoma is a pediatric cancer characterized by chimeric EWSR1-ETS fusion oncogenes (in 85% EWSR1-FLI1). In our recent study, we showed that EWSR1-FLI1 hijacks the developmental transcription factor SOX6, which contributes to tumor growth but also increases sensitivity toward oxidative stress.
The invisible enemies: COVID-19 and Multiple Myeloma
Binod Dhakal, Anita D'Souza, Saurabh Chhabra, Parameswaran Hari,
Medical College of Wisconsin
Milwaukee, WI, USA
