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Behind the Paper

The real stories behind the latest research papers, from conception to publication, the highs and the lows

Behind the Paper

Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia

Cancer cachexia is characterized by weight loss and skeletal muscle wasting. The up-regulation of catabolism and down-regulation of anabolism result in concometabolite accumulation. This study focused on genetic mutation-mediated metabolic reprogramming in cancer cachexia progression.

Sep 24, 2023

Behind the Paper

Exploring Prolonged Drug Action: The Role of Epichaperome Agents

Discover the secret behind prolonged drug action. Epichaperome target binding by zelavespib and icapamespib defies rapid clearance, shedding light on effective disease treatment.

+1

Gabriela Chiosis and 1 other

Sep 22, 2023

Clonal dynamics and stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma

npj Precision Oncology

Behind the Paper

Clonal dynamics and stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma

Sep 20, 2023

A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma

Behind the Paper

A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma

Sep 14, 2023

Behind the Paper

Identification of DHX40 as a candidate susceptibility gene for colorectal and hematological neoplasia

+1

Alisa Olkinuora and 1 other

Sep 11, 2023

Targeting SOD1 via RNAi with PEGylated Graphene Oxide Nanoparticles in Platinum-Resistant Ovarian Cancer

Cancer Gene Therapy

Behind the Paper

Targeting SOD1 via RNAi with PEGylated Graphene Oxide Nanoparticles in Platinum-Resistant Ovarian Cancer

+2

Attila Szénási and 2 others

Sep 09, 2023

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

Behind the Paper

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

+3

Peter Bailey and 3 others

Sep 07, 2023

Cholinergic T cells at the center of neuro-immuno-oncology

Behind the Paper

Cholinergic T cells at the center of neuro-immuno-oncology

Sep 06, 2023

Discovery of Multiple Cancer Signatures in Circulating RNA and Extracellular Vesicles

Communications Biology

Behind the Paper

Discovery of Multiple Cancer Signatures in Circulating RNA and Extracellular Vesicles

+2

Hyun Ji Kim and 2 others

Sep 04, 2023

British Journal of Cancer

Behind the Paper

Selection of Treatment Options for Locally Advanced Rectal Cancer: An MRI-based Risk Stratification Scoring System

We developed the mrDEC scoring system to accurately predict the prognosis of patients with LARC and to distinguish true high-risk patients from low-risk patients.

Sep 02, 2023

Nature Communications

Behind the Paper

Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

This study presents an optimized proteogenomic workflow for the discovery of neoantigens (in particular RNA-derived neoantigens) in a pan-cancer cohort and sheds light on the entity-agnostic prevalence of HLA-I peptide presentation of RNA processing events for tumor targeting.

Michael Hiltensperger

Aug 31, 2023

Exploring HCMV's emerging role as an oncovirus: induction of transformed ovarian epithelial cells by Human Cytomegalovirus (HCMV)

Behind the Paper

Exploring HCMV's emerging role as an oncovirus: induction of transformed ovarian epithelial cells by Human Cytomegalovirus (HCMV)

+2

Georges Herbein and 2 others

Aug 30, 2023

British Journal of Cancer

Behind the Paper

PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies

+1

Vishnu Kumarasamy and 1 other

Aug 28, 2023

Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma

Nature Collections

npj Systems Biology and Applications

Behind the Paper

Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma

+1

Claudio Monteiro and 1 other

Aug 22, 2023

npj Precision Oncology

Behind the Paper

Behind the Paper: “Molecular Disparities in Colorectal Cancers of White Americans, Alabama African Americans, and Oklahoma American Indians”

Hiroshi Y. Yamada, Upender Manne, Chinthalapally V. Rao

Hiroshi Y. Yamada

Aug 21, 2023

Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency

Nature Communications

Behind the Paper

Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency

Maddalena Marconato

Aug 21, 2023

Nature Communications

Behind the Paper

Harnessing the interactions between light and nanoparticles: expanding the therapeutics options for glioblastoma treatment

+1

Qi Cai and 1 other

Aug 18, 2023

The burden of cancer has increased in old people with type 2 diabetes, and inequalities persist

Behind the Paper

The burden of cancer has increased in old people with type 2 diabetes, and inequalities persist

Aug 17, 2023

Targeting by PG545 enhances PARP inhibitor response in ovarian cancer

Behind the Paper

Targeting by PG545 enhances PARP inhibitor response in ovarian cancer

+1

Viji Shridhar and 1 other

Aug 15, 2023

Behind the Paper

Auxiliary Diagnosis of Papillary Thyroid Carcinoma Based on Spectral Phenotype

This poster is about the paper "Auxiliary Diagnosis of Papillary Thyroid Carcinoma Based on Spectral Phenotype" published at Phenomics.

Aug 15, 2023