In our latest manuscript in Leukemia, we describe a putative additional mechanism for MYC deregulation downstream of MLL. We further demonstrate that IRAK1/4 inhibitor might improve the efficacy of BET inhibitor through synergistically downregulating MYC in MLL leukemias.
CUL4B is first identified as a mental retardation gene in our laboratory. We further confirmed that CUL4B also functions importantly in cancer. In our latest publication, we revealed CUL4B sustained the oncogenic properties in bladder cancer through regulating miR-372/373-PIK3CA/AKT axis.
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