Behind the Paper

The real stories behind the latest research papers, from conception to publication, the highs and the lows.

Efficacy of first-line atezolizumab combination therapy in patients with non-small cell lung cancer receiving proton pump inhibitors: post hoc analysis of IMpower150

Proton pump inhibitors (PPIs) are commonly used concomitant to cancer treatment and they induce gut microbiota changes. It’s increasingly apparent that gut dysbiosis can reduce the effectiveness of immune checkpoint inhibitors (ICI). However, little is known on PPI effects on outcomes with ICIs.
Go to the profile of Ashley Hopkins
Nov 09, 2021

The role of the stroma, encompassing pancreatic stellate cells and extracellular matrix, in the biology and chemoresistance of pancreatic cancer

Our report entitled “3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing” (PMID: 23446043) has its ten years anniversary. Herein we present the story "After the Paper" on the background of two recent publication from our group.
Go to the profile of Rainer Heuchel
Oct 15, 2021