Volume 1 Issue 5, May 2020
Paper: The T cell differentiation landscape is shaped by tumour mutations in lung cancerTracing the effects of tumor mutations on T cell differentiation (Nature Cancer).
Behind the Paper: Coupling T cell differentiation to the lung cancer mutanome via neoantigen surveillance by James Reading.
Behind the Paper: Tumour neoantigens: the double edged sword that drives immune failure by Ehsan Ghorani.
Image: QuezadaLab, UCL Cancer Institute.
Cover design: Allen Beattie.
Volume 25 Issue 10, October 2019
Paper: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse (Nature Medicine).
Behind the Paper: Circulating tumour cells in the pulmonary vein of early stage non small cell lung cancer patients: what do they tell us about risk of relapse after surgery and seeding of metastasis? By Francesca Chemi. And video!
Image: Jeroen Claus.
Cover design: Erin Dewalt.
Volume 567 Issue 7749, 28 March 2019
Paper: Neoantigen-directed immune escape in lung cancer evolution (Nature).
Image: Jeroen Claus/Phospho Biomedical Animation
TRACERx is a 9-year research programme which aims to integrate new technologies to understand the evolution of lung cancer - some of the latest findings are published today in a special collection by Nature.