Thomas G. P. Grünewald

Division Head, German Cancer Research Center (DKFZ)
  • German Cancer Research Center (DKFZ)
  • Germany

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Ewing sarcoma is a pediatric cancer characterized by chimeric EWSR1-ETS fusion oncogenes (in 85% EWSR1-FLI1). In our recent study, we showed that EWSR1-FLI1 hijacks the developmental transcription factor SOX6, which contributes to tumor growth but also increases sensitivity toward oxidative stress.