Several forms of regulated cell death, including apoptosis, necroptosis, pyropotosis, and ferroptosis, play crucial roles in maintaining tissue homeostasis. Our lab is interested in the mechanisms how impairment of regulated cell death contributes to the development of many pathological conditions, such as chronic inflammation, autoimmune diseases, and cancer. A better understanding underling the mechanisms will be essential to develop novel strategies to treat these diseases.

To achieve this goal, we have been working on various murine models showing an increase in cell death and live cell imaging of necroptosis by a newly developed FRET biosensor (SMART) in vitro and in vivo. We are also working on a cytokine, interleukin (IL)-11 that is induced by oxidative stress and promotes tumor development.