Saskia Rudat

Postdoctoral Research Fellow, University Hospital Tübingen
  • University Hospital Tübingen
  • Germany

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CUX1 haploinsufficiency antagonizes apoptosis to sustain AML

Monoallelic loss of CUX1 confers poor prognosis, but its role in acute myeloid leukemia (AML) development remains obscure. Here, we show that CUX1 deletion induces CFLAR-mediated apoptosis inhibition crucial for AML survival and establish CFLAR as a therapeutic target in this high-risk AML subtype.

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