Tian-Yu Song

Ph.D., ShanghaiTech University
  • ShanghaiTech University
  • China

About Tian-Yu Song

I have always been intrigued by how cancer escape clearance by host immunity or therapeutic agents. To answer this question, I designed and performed multiple CRISPR library screenings in engrafted tumors with different immune selection, cancer-immune cell co-cultures and drug-induced cytotoxicity systems. I identified the core microRNA machinery (Nature Communications, 2021) or the epigenetic regulator KDM6A-KMT2D complex (In Submission) as key cancer-intrinsic modulators of response to T cell-mediated immunity and immunotherapy from tumor evolution. Also, I uncovered the regulation of CRBN level and CRL4CRBN E3 ubiquitin ligase activity by COP9 signalosome (Leukemia, 2019) and another E3 ligase SCFFbxo7 (Plos Genetics, 2018), indicating a critical role of such regulation for immunomodulatory drugs and their derivates (PROTAC and molecular glue degraders) to induce oncoprotein degradation and cytotoxicity. As a recognition of my research achievements, I have been awarded Super Post-doctoral Fellowship of Shanghai City, General and Special Programs of Postdoctoral Science Foundation of China, and National Natural Science Foundation of China for Young Scholar.

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Here we investigate the impact of different immune pressure on tumor clonal dynamics and immune evasion mechanism, by combining massive parallel sequencing of immune edited tumors and CRISPR library screens in syngeneic mouse tumor model and co-culture system.

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